Friday, October 21, 2011

FW: October 2011--RBC storage duration: Is older riskier

 
 




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RBC storage duration:
Is older riskier?
Anne Paxton

From across a hospital room, the average person should have no problem determining the blood type of a unit of red blood cells, as it's likely to be displayed prominently in large block letters. But another piece of information is in much smaller print: the unit's expiration date. Backtrack 42 days from that, and in most cases you'll arrive at the date when the blood was drawn from a donor, hence how long it has been on the shelf.

That bit of small print is garnering a lot of attention these days. The question is, if the expiration date hasn't been reached, does it matter how old the unit is? It may—or it may not.
Dr. Philip Spinella (left), shown here with Dr. Allan Doctor, says a survey found 66 percent of blood bank directors at children's hospitals are concerned about giving old blood, but 60 percent also say there's too little evidence to change practice. Several studies are underway.
It's been three years since a study conducted at the Cleveland Clinic was reported in the New England Journal of Medicine, then splashed across the mainstream press, startling many people with the finding that cardiac surgery patients who get fresher blood seemed to have better outcomes. The study put the phenomenon of a potentially harmful red blood cell "storage lesion" squarely on the map, igniting public worries that older blood was not as good.

But as critics of the Cleveland Clinic study weighed in, charging that it was flawed research, a string of questions has been left unanswered. Should clinicians and patients be concerned about how long a unit of red cells has been stored? Should the FDA-imposed storage limit of 42 days be shortened? Should certain categories of patients routinely receive fresher red cells? Or could commercial red cell treatments or storage techniques limit the storage lesion's potentially negative effects? [more]

Leica Microsystems

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